Lucy in the sky with protein: Did we find the key to LSD’s psychoactive potency?

Noted: But it is still unclear exactly how, once bound to LSD, these receptor proteins go on to create the specific, often bizarre effects of LSD — like the frequently reported destruction of one’s sense of self, or careening uncontrollably into one’s deepest, most personal memories and emotions. The work only studied two of 40 known receptors that LSD touches in the brain, said Nicholas Cozzi, a pharmacologist at the University of Wisconsin-Madison who was not involved with the study.