Some scientists believed from the start that it would be possible to repurpose this basic cellular function for medicine. In 1990, a Hungarian-born scientist at the University of Pennsylvania, Katalin Kariko brashly predicted to a surgeon colleague that his work would soon be obsolete, replaced by the power of messenger RNA therapies. That same year, a team at the University of Wisconsin startled the scientific world with a paper that showed it was possible to inject a snippet of messenger RNA into mice and turn their muscle cells into factories, creating proteins on demand.