But what makes the mutation “weird and unique” is that it appears to set the stage for other variants, says Kyle Wolf, a biophysicist at the University of Wisconsin-Madison. SARS-CoV-2 infects cells faster when it has more RBDs flipped up—but that also makes its spikes more likely to fall apart before they find their target. A virus with DOUG appears to be more stable: When its RBDs up, they wedge together, holding the spike proteins together until it finds a host, Wolf explains. The mutation could be required for other variants, which opened the spike even further, but needed a way to stabilize the package, says Sophie Gobeil, a structural biologist at Duke University.
Office of Strategic Communication