In pregnant women, the effects are particularly impactful, as such DNA changes not only play out in the mother, but in the developing fetus and also the germ cells within the fetus, the precursors to sperm and eggs.
“This means that malnutrition has the potential to influence three generations—the mother, her child, and her grandchild,” says Hasan Khatib, a professor of genetics and epigenetics at the University of Wisconsin-Madison. Such effects have been seen in the descendants of both the Great Chinese Famine and the Dutch Hunger Winter during World War II, where the children of babies starved in the womb carry genetic alterations that have placed them at higher risk of diabetes, as well as addiction and even schizophrenia in adulthood.