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Seely on Science: Chemical agents wage war against bacteria

Scratch the surface of just about any branch of science and you?ll find chemistry. Yet it remains in some ways the invisible science as its practitioners toil away ? too often unnoticed and underappreciated ? figuring out the chemical underpinnings of the natural world and chemical solutions to some of our thorniest problems.

On the UW-Madison campus, for example, chemistry is showing us a way to better understand and fight one of the most dangerous of the many bacteria that have become resistant to antibiotics. The bacterium is called Acinetobacter baumanni, or A. baumanni, and it proved a terror in front-line hospitals in Iraq, earning the nickname “Iraquibacter.” But in her laboratory at UW-Madison, chemist Helen Blackwell and her colleagues have spent a decade unlocking some of the chemical secrets of A. baumanni and may be on the verge of finding a new weapon against the stubborn pathogen. Chemistry, it turns out, underlies that bacterium’s ability to become deadly.