To fill in this knowledge gap, the research team (led by scientists at the University of Wisconsin-Madison) analyzed two bacterial samples of Escherichia coli (E. coli)—one located on Earth, the other on the ISS, and both infected with what is known as a T7 bacteriophage. Eventually, they found that while the outcome of the arms race remained the same in each location—the bacteriophage eventually infected its bacterial prey—there were distinct differences in how this battle played out between the two samples.
“Space fundamentally changes how phages and bacteria interact: infection is slowed, and both organisms evolve along a different trajectory than they do on Earth,” the authors wrote. “By studying those space-driven adaptations, we identified new biological insights that allowed us to engineer phages with far superior activity against drug-resistant pathogens back on Earth.”