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Category: Research

Are Controls on Bird Flu Research a Good Idea?

Scientific American

Two scientists who independently concocted potentially dangerous strains of bird flu viruses?and have had the bioweapons community in a tizzy for the past month with the pending publication of their work?today said that they would suspend their research for 60 days.  The announcement is intended to be a kind of time out, a chance for everyone to catch up with the realization that influenza is no longer solely a matter of public health, but is now a potential bioweapon.

Worry over flu virus experiments was unwarranted

Los Angeles Times

If you were paying attention to the flap over two recent flu experiments involving ferrets, you may have come away with the impression that scientists all but waved a red flag in front of terrorists and said, “Here?s a perfect biological weapon ? help yourselves.”

On Campus: State funding per-student at UW-Madison dropped by 9.3% in past decade, report found

Wisconsin State Journal

The state of Wisconsin reduced per-student funding at UW-Madison by 9.3 percent between 2002 and 2010, after adjusting for inflation, according to data released today by the National Science Board, the policy-making body of the National Science Foundation. State funding per student at UW-Madison dropped from $10,275 to $9,324, according to the report. Trends in state funding are even bleaker at other major public research universities, the science board found.

Ask the Weather Guys: Do the tropics influence the weather in Madison?

Wisconsin State Journal

A. It may seem implausible at first glance, but current research in the Department of Atmospheric and Oceanic Sciences at UW-Madison is exploring connections between tropical cyclones (hurricanes) near the Philippines and extreme weather events in southern Wisconsin.The connection appears to derive from unusual jet stream structures forced by the outflow from the hurricane at high levels in the atmosphere.

Benefits of H5N1 research do not outweigh the risks

Milwaukee Journal Sentinel

Should we purposefully engineer avian flu strains to become highly transmissible in humans? In our view, no. We believe the benefits of this work do not outweigh the risks. (A column by Thomas V. Inglesby, the chief executive officer and director of the Center for Biosecurity of UPMC in Baltimore and Anita Cicero, chief operating officer and deputy directo and D.A. Henderson, a distinguished scholar.)

Research on deadly virus may need more safeguards

Research on the H5N1 virus is critical to public health. But it must be done safely – and it must be done within an internationally monitored system that has clear rules for how the results of the research can be distributed. The experiments in Madison and Rotterdam offer an opportunity to put such a regime in place.

Stressed? Call Mom, Researchers Conclude

ABCNEWS.com

Moms feed us, read to us, clap the loudest, cry the hardest, sit front row at recorder recitals, write notes in our lunchboxes and promise that the hole in our hearts after a break-up won?t stay there forever.

The Risks of Dangerous Research

The Scientist

In the wake of news last month that researchers had created a version of the deadly bird flu that was easily transmissible by air, a heated debate has arisen in the scientific community about whether or not the research should be published. But some experts are taking the discussion a step further back, and wondering why the research was conducted at all.

Rick Bogle: UW stories left out bad news related to animals

Capital Times

Dear Editor: Two articles in the Jan. 4-10 Cap Times were noteworthy because of the similar topic of their omissions. The first, ?A brighter year ahead,? looked back on UW-Madison?s past year but made no mention of the university?s successful lobbying of lawmakers to exempt its staff from Wisconsin?s crimes against animals statutes. The second article, a retrospective look at the retiring UW-Madison library director?s tenure, made no mention of the library?s role in or silence about the 2005 shredding of a cataloged 628-piece collection of 15 years of video records from the UW Primate Center, after it refused to provide a copy of one record that was requested as part of a public records request.

New stem cell classroom at MATC triples student capacity

Wisconsin State Journal

With seven biosafety hoods, plenty of space and a big screen to project images from microscopes, a new stem cell classroom at Madison Area Technical College is a major advance from the cramped quarters where students previously learned how to grow the cells. The expanded space, dedicated Tuesday, means up to 24 students can be trained each semester, up from eight before. The added capacity could supply more workers for the burgeoning stem cell industry in Madison and around the country.

Cognitive Skills at 45: Middle-Aged Brain More Resilient (TIME.com)

Researchers suspect that one reason middle-aged people are more resilient is that their brains have learned to accentuate the positive and eliminate the negative. Using brain imaging to peek inside that 3 lb. of gray and white matter, researchers at the University of Wisconsin found that in younger adults, the amygdala, the brain?s emotional nut, was activated when they looked at upsetting as well as uplifting images.

Number of families seeking vaccine exemptions rises in Wisconsin

Wisconsin State Journal

Kai Hirata?s parents feed him healthy foods. When cold and flu season hits, they increase his vitamin C. But they haven?t given the 7-year-old any vaccines. Diseases such as measles, which sprang up around the country last year, including in Milwaukee and Minneapolis, don?t worry them.

“As more people get waivers, our herd immunity goes down to the point where the entire community is at risk,” said Dr. James Conway, a UW Health pediatric infectious diseases specialist who is on the board of the Dane County Immunization Coalition.

UW Grad Exposed In ’60 Minutes’ Fraud Report

WISC-TV 3

MADISON, Wis.– A CBS News eight-month investigation found a University of Wisconsin-educated doctor promised cures that science could not provide. Dr. Dan Ecklund received his medical degree from UW in 1987, but his medical license was revoked in 2005, according to state records in Alabama. On Sunday night, “60 Minutes” accused Ecklund of peddling fake stem cell therapies to a family whose son has cerebral palsy, a disease with no known cure. With so much research done on potential therapies and stem cells in Madison, local scientists are quick to distance themselves from Ecklund. Still, Dr. David Gamm, an ophthalmologist and stem cell researcher at UW, said similar attempts at fraud are all too common.

Federal government approved security at UW bird flu lab

Milwaukee Journal Sentinel

While the New York Times is calling for an influenza virus created in an academic research lab in the Netherlands to either be destroyed or moved to government-controlled laboratories with the highest containment rating because of the danger the virus poses, little is known publicly about another contagious virus engineered in a University of Wisconsin-Madison lab.

Professor defends safety of UW’s bird flu research

Milwaukee Journal Sentinel

The professor who oversees biosafety for the University of Wisconsin-Madison?s controversial avian influenza research responded Monday to mounting criticism about the necessity and safety of the research, saying “ongoing research with H5N1 remains salient.”

Seeing Social Media as Adolescent Portal More Than Pitfall

New York Times

More than a hundred years ago, when the telephone was introduced, there was some hand-wringing over the social dangers that this new technology posed: increased sexual aggression and damaged human relationships. ?It was going to bring down our society,? said Dr. Megan Moreno, a specialist in adolescent medicine at the University of Wisconsin-Madison. ?Men would be calling women and making lascivious comments, and women would be so vulnerable, and we?d never have civilized conversations again.?

A Year That Was Good To Beets

National Public Radio

Does all this constitute a beet renaissance? Irwin Goldman says, absolutely, yes. He breeds beets at the University of Wisconsin, where he?s a professor of horticulture. He has been waiting for this renaissance for years.

UW scientists hope to unlock cosmic secrets with dynamo experiment

Wisconsin State Journal

Scientists could better understand how solar flares disrupt cellphone calls, wipe out power grids and knock out satellites, thanks to an aluminum sphere at UW-Madison that resembles the Death Star from “Star Wars.” The 11,000-pound hollow vessel, built to stir gas at 500,000 degrees Fahrenheit and replicate the process that creates the sun?s magnetic field, was installed this week in Sterling Hall.

Tech and biotech: Bio bigwigs to converge on San Francisco this week

Wisconsin State Journal

An elite group of up-and-coming biotech companies from around the country – as well as a number of the nation?s biggest, most successful health-related firms – will be making presentations this week to the investment community at the 30th annual J.P. Morgan Healthcare Conference in San Francisco, Monday through Thursday. Cellular Dynamics International, the Madison company founded by UW-Madison stem cell pioneer James Thomson, will be among them. It will be the second year that CDI has been invited to participate in the event, considered the biggest and most prestigious in life sciences in the U.S., said CDI chief executive Robert Palay.

Doug Moe: Maybe it will be a (mostly) silent movie

Wisconsin State Journal

A man once hailed as the greatest comedy filmmaker in the world, who gave away almost everything to search his soul, now wants to make a movie about a man who stopped speaking and riding in cars for 17 years. One of them is in Madison, carrying a film script in his backpack. I bought him a cup of coffee last week.

“He asked who I wanted to play me in the movie,” John Francis said. Francis, 65, is an associate visiting professor at the Nelson Institute for Environmental Studies, and one of the more intriguing characters ever to land on the UW-Madison campus.

Curiosities: Why do exotic insects multiply and then decline?

Wisconsin State Journal

Q. I notice fewer Asian lady beetles during the warmer months. Is it typical for a population of exotic insects to explode and then decline?

A. It often is, says Phil Pellitteri, distinguished faculty associate in the entomology department at UW-Madison. “The Asian lady beetle fell off the face of the Earth this year, and we have been seeing a decline for four or five years,” Pellitteri said. “I?ve gone to places where I used to see a tremendous number, and they are few and far between.”

Ask the Weather Guys: What causes wind gusts?

Wisconsin State Journal

A. A wind gust is a sudden, brief increase in the speed of the wind followed by a lull. According to National Weather Service observing practice, gusts are reported when the peak wind speed reaches at least 18 mph and the variation in wind speed between the peaks and lulls is at least about 10 mph.

An Engineered Doomsday

New York Times

Scientists have long worried that an influenza virus that has ravaged poultry and wild birds in Asia might evolve to pose a threat to humans. Now scientists financed by the National Institutes of Health have shown in a laboratory how that could happen. In the process they created a virus that could kill tens or hundreds of millions of people if it escaped confinement or was stolen by terrorists.

Ritalin’s brain target pinpointed by UW researchers

Capital Times

The drug Ritalin has been used for years to help people with attention deficit hyperactivity disorder (ADHD). But it wasn?t until now that researchers at UW-Madison have discovered where in the brain the drug works. Psychology professor Craig Berridge and graduate student Robert Spencer have identified the upper portion of the brain?s prefrontal cortex as the key area where Ritalin works.

Renowned evolutionary biologist and popular professor James Crow dies at 95

Wisconsin State Journal

James F. Crow, one of the world?s most eminent evolutionary biologists and a popular UW-Madison professor for more than 40 years, died Wednesday in Madison. He was 95. The university named its Institute for the Study of Evolution after Crow in 2009.

“Jim was a major figure in the history ? up to the present ? of evolutionary genetics,” said John Hawks, an associate professor of anthropology. In addition to his research on the behavior of genes and the effects of radiation on the human mutation rate, Crow served on a number of groundbreaking national committees. He chaired a national committee that compiled a report on the use of DNA evidence in the courtroom.

Science and Security Clash on Bird-Flu Papers

Chronicle of Higher Education

It was the week before Christmas, and D.A. Henderson was alarmed about germs. He isn?t easily rattled: Dr. Henderson led the successful worldwide effort to eradicate smallpox in the 1970s, and he directed the U.S. Office of Public Health Emergency Preparedness after the deadly anthrax letter attacks and the destruction of the World Trade Center in 2001. But recently not just one but two laboratories had engineered the virus known as bird flu to make it easily transmissible?through the air, among mammals?and that was a scary development. “Compared to plague or to anthrax, this one has a potential for disaster that dwarfs all others,” says Dr. Henderson, now a distinguished scholar at the Center for Biosecurity of the University of Pittsburgh Medical Center. “Given our flu-vaccine capacity, which is limited, this could be a catastrophe if it gets out.” The experiments shouldn?t have been done, in his view, and?partly because they could give terrorists a blueprint for making a more deadly form of H5N1 avian-influenza virus?they certainly shouldn?t be published.

UW-Madison virologist Yoshihiro Kawaoka and Ron Fouchier, a virologist at the Erasmus Medical Center in the Netherlands, are mentioned in this article.

Editorial: On Wisconsin

WISC-TV 3

In a few hours it?ll be all about the football. But it?s been interesting these last several days to hear University of Wisconsin administrators and fans talk about the image boost UW gets from playing in the Rose Bowl. If you haven?t seen the new UW promotional ad, you?ll see it during the game, but it highlights some of the discoveries and research that originated at UW and it?s impressive.

Emmett L. Bennett Jr. Dies at 93, Expert on Ancient Script, Dies at 93 (NYTimes.com)

New York Times

Emmett L. Bennett Jr., a classicist who played a vital role in deciphering Linear B, the Bronze Age Aegean script that defied solution for more than 50 years after it was unearthed on clay tablets in 1900, died on Dec. 15 in Madison, Wis. He was 93. His daughter Cynthia Bennett confirmed the death.

Professor Bennett was considered the father of Mycenaean epigraphy ? that is, the intricate art of reading inscriptions from the Mycenaean period, as the slice of the Greek Bronze Age from about 1600 to 1200 B.C. is known. His work, which entailed analysis so minute that he could eventually distinguish the handwritings of many different Bronze Age scribes, helped open a window onto the Mycenaean world.

Ask the Weather Guys: What were the top Wisconsin weather events for 2011?

Wisconsin State Journal

Each season in 2011 had a memorable weather event, some with negative impacts. There were two good snow storms in February. The Groundhog Day blizzard had wind gusts of up to 60 mph and snowfall depths ranging from 1 to 2 feet. That resulted in snow drifts of 6 to 10 feet. The second storm occurred on February 20-21 with snow accumulations between 8 and 15 inches. Freezing rain and sleet also fell across southern Wisconsin.

….During the year, 10 people were directly killed by weather events: one person from a blizzard, one from lightning, one from a tornado, one from non-tornadic thunderstorm winds, one from flooding and five during the July heat wave.

Anthony S. Fauci, Gary J. Nabel and Francis S. Collins: Dangerous flu virus research a risk worth taking

Capital Times

A deadly influenza virus has circulated widely in birds in recent years, decimating flocks but rarely spreading to humans. Nonetheless, because of its persistence in bird flocks, this highly pathogenic virus has loomed as a major public health threat. Seasonal influenza kills less than 1 percent of the people it infects. In contrast, human infections with the H5N1 virus, though exceedingly rare, are fatal in most cases. Should this virus mutate in a way that allows it to be transmitted as efficiently among people as seasonal influenza viruses are, it could take an unprecedented toll on human life.

A number of important scientific and public health questions regarding this virus remain unanswered, including the likelihood of such mutations arising and the mechanisms by which they may occur. Two recent studies co-funded by the National Institutes of Health (including research conducted by UW-Madison bird flu expert Yoshihiro Kawaoka) have shed light on how this potentially grave human health threat could become a reality.

How to Research Deadly Germs Without Helping Terrorists

Bloomberg News

Bird flu kills more than half the people who catch it. The saving grace of H5N1 is that it?s not easily spread among humans. Almost all of the 600 people who have been infected by the virus in its 14-year history have picked it up from infected poultry.

Patients donate locally to support medical research for personal connections

Wisconsin State Journal

When Greg Szymanski started raising money for eye research, he decided not to give it to a foundation far away. He donated the money to the lab of Dr. David Gamm, a UW-Madison retina specialist using stem cells to better understand and treat vision loss. “I wanted to help right here, where we have specialists who work on these diseases,” said Szymanski, 62, of Madison, who lost most of his sight seven years ago. Unlike government grants that pay for most medical research, Szymanski?s money comes with few restrictions, Gamm said.

Citizen Dave: We might have been a part of it, New York, New York

Isthmus

Imagine if the University of Wisconsin had a campus in New York City dedicated to competing with MIT and Stanford for being the premiere science and high tech research campus in the nation. That possibility was on the table recently when Mayor Michael Bloomberg announced a competition to create a new world-class science campus on underutilized acreage on Roosevelt Island in the East River. The land for the new campus would be given free to the university that competed successfully for it. Bloomberg was offering a $400 million grant in land and infrastructure.

Medtronic paid millions to influential UW chairman

Milwaukee Journal Sentinel

Paul Anderson, an orthopedic surgeon at the University of Wisconsin-Madison, gets so much money from the medical device firm Medtronic that the university put its most stringent oversight on the relationship.

One of the requirements is that Anderson, who has received $225,000 in consulting fees from Medtronic in 2008 through 2010, has to meet annually with his department chairman to review the relationship and its potential influence on his university activities.

But the chairman, Thomas Zdeblick, got more than 25 times that amount from Medtronic himself during the three years. And a new accounting by the Journal Sentinel and MedPage Today shows he received more than $25 million in royalties from the company since 2003.

Science and Censorship: A Duel Lasting Centuries

New York Times

The specter of censorship loomed over science last week with news that a federal advisory panel had asked two leading journals to withhold details of experiments out of fear that terrorists could use the information to make deadly flu viruses ? the first time the government had interceded this way in biomedical research.

Security in H5N1 Bird Flu Study Was Paramount, Scientist Says

New York Times

The National Science Advisory Board for Biosecurity, concerned about bioterrorism and a worldwide pandemic, has for the first time ever urged scientific journals to keep details out of reports that they intend to publish on a highly transmissible form of the bird flu called A(H5N1), which has a high death rate in people.

A Conversation With Jack Williams (The Atlantic)

Atlantic Monthly

In his research, Jack Williams, director of the Nelson Institute Center for Climatic Research, studies the impact climate change had at the end of the last ice age–around 15,000 years ago–when global temperatures rose by 9°F.

By analyzing ancient materials trapped in lake beds, he and his colleagues in the field have come to some startling conclusions. For one, small fluctuations in global temperature can cause large-scale biological changes across the planet, including mass migrations and extinctions.