Proteins are the workhorses that run all biological systems. Controlling when and how a protein performs its function provides bioengineers with exquisite control to manipulate or monitor a biological system. In this paper, researchers at Northwestern and the University of Wisconsin–Madison demonstrate a powerful design strategy for splitting bioactive proteins into fragments that only recombine under specific conditions.
Category: Research
Risk for atherosclerotic CVD in lupus nephritis ninefold higher with renal arteriosclerosis
“Previous studies demonstrated that patients with lupus nephritis who had atherosclerotic cardiovascular disease (ASCVD) were significantly younger than those without lupus nephritis, and ASCVD risk was 42 times higher in patients with lupus nephritis who were aged 30 to 39 years,” Shivani Garg, MD, MS, of the University of Wisconsin, Madison, told Healio Rheumatology. “The risk of ASCVD starts early, at the time of lupus nephritis diagnosis. Often traditional risk factors alone do not explain the accelerated ASCVD risk in such patients.
UW-Madison’s research rank, once among top 5 in US, remains in 8th place for 2nd year
UW-Madison ranked eighth in research spending among hundreds of institutions in the latest year — again falling outside the top echelon where it had perched for decades — according to the latest figures by the National Science Foundation.
UW-Madison ranks 8th in national research rankings for public, private universities
UW-Madison ranked eighth place in the national research rankings for both public and private universities, the same ranking as the last survey covering the 2018 fiscal year. UW ranked sixth among public universities, which was also the same ranking as in fiscal year 2018.
UW discovery changes current understanding of insulin pathway
University of Wisconsin researchers and their collaborators at Yale published findings in early November which changed current understandings of the way cells in the pancreas regulate the release of insulin, UW announced in a press release.
What is liquid nitrogen and when is it deadly?
Liquid nitrogen is so cold that it freezes anything it touches, according to the University of Wisconsin-Madison. It clocks in around 320 degrees below freezing. Because it’s so cold, liquid nitrogen immediately boils when it touches anything room temperature, which is what causes the cloudy smoke seen in fancy cocktails and frozen desserts.
Young People Spreading Covid a Concern in Rapidly Aging Japan
Noted: One way to appeal to youth on Covid-19 is by placing the wellbeing of their social group on their shoulders, said Dominique Brossard, a professor specializing in science communication at University of Wisconsin at Madison.
She pointed to the decades-old “Friends don’t let friends drink and drive” slogan in the U.S. as one successful campaign that helped lower incidence of youth drunk-driving. Simply relaying information about the virus may have limited effectiveness with the younger generation, who are accustomed to being bombarded with a constant stream of content.
How Laura Albert Helped Make Election Day in Wisconsin Safer Amid the Pandemic
When public servants face a challenge, AAAS Member and newly elected 2020 AAAS Fellow Dr. Laura Albert finds solutions. Whether helping police tackle the opioid crisis, or assisting election officials in protecting voters during a deadly pandemic — which was one of her most recent feats — the University of Wisconsin-Madison professor uses mathematical models and analytics to recommend safe, economical and often innovative remedies.
Puppy prints and wall illusions found in 1,500-year-old house in Turkey
Noted: The house was in use for more than 200 years before an earthquake destroyed it during the early seventh century. Excavation by the Sardis Expedition of Harvard University is being conducted with the permission of the Turkish government, and is directed by Professor Nicholas Cahill of the University of Wisconsin–Madison.
UW-Madison SARS-CoV-2 research maps how virus spreads, evolves
Dr. Thomas Friedrich, a professor of virology at UW-Madison’s School of Veterinary Medicine, says his lab focuses on understanding how viruses that cause pandemics overcome evolutionary barriers to get transmitted.
In-person learning returns at Glenbrook high schools; district rolls out testing program for students, staff
All students participating in not only in-person learning but also other in-person activities are required to participate in the weekly testing, according to officials. Students will be using self-administered, non-diagnostic saliva tests developed by scientists at the University of Wisconsin-Madison.
Will the real retirement crisis please stand up?
These life-cycle models often find that there is a much smaller retirement crisis than suggested by a focus on replacing preretirement income. For example, one 2008 study—“Are All Americans Saving ‘Optimally’ for Retirement,” by John Karl Scholz and Ananth Seshadri of the University of Wisconsin-Madison—found that only 4% of households had a net worth that was below their optimal levels. The NRRI at the time was 44%.
Trying To Be Happier Won’t Work. Here’s What Will, According To Science.
Another key point? It doesn’t make sense to be happy all the time. “The goal isn’t to be happy 24/7,” Richard Davidson, founder and director of the Center For Healthy Minds at the University of Wisconsin-Madison, told HuffPost.
Covid Face Masks Are Disrupting a Key Tool of Human Communications, New Research Shows
In that test, the children correctly identified the emotional expression on uncovered faces about 66% of the time, well above the odds of just guessing, psychologist Ashley Ruba at the University of Wisconsin-Madison said. Looking at faces in surgical-type masks, however, the children were only able to correctly identify sadness about 28% of the time, anger 27% of the time, and fear 18% of the time.
“For very young children, I think it is still an open question as to how they’ll navigate these situations,” said Dr. Ruba, who studies how children learn to understand other people’s emotions. “Infants can use all these other cues, like tone of voice.”
Digital divide: Health, education, prosperity depend on high-speed internet
But the problem may be worse than we thought, according to a new UW Extension study, with implications for health, education and prosperity — problems that are further exacerbated by the COVID-19 pandemic, which has pushed nearly every aspect of daily life — from business to school and even health care — online. “People are choosing to live in places they can have access,” said Tessa Conroy, an assistant professor of applied economics and the lead author of the study. “More and more it’s connected to so many facets of life.”
How low-income people are spending their $600 pandemic stimulus payments
Noted:
It’s too soon for scholars to have studied how those in poverty have used their $600 stimulus checks. But in a study of the way Americans spent their first round of pandemic-related stimulus checks in April — many of those around $1,200 each — scholars from the University of Wisconsin and the University of Virginia showed that people spent a great deal of their allotment on food, helping to stave off hunger.
U OF I STUDY: Bears Like Baths, too
Noted: Their study was published in “Functional Ecology,” a journal of the British Ecological Society, and involved a collaborative team of researchers from the U of I, Washington State University, the University of Wisconsin-Madison and U.S. Geological Survey. It looked at how the risk of heat stress from a warming climate might affect milk production in grizzly bears. It also investigated how bears respond, including their use of soaking pools.
What’s the protocol for creating a healthy new human when you subtract Earth from the equation?
Noted: Scientists at the University of Wisconsin Madison are blasting bacteria with high doses of ionizing radiation to watch them evolve radiation resistance in real time and study which genes are involved.
If You Have These Conditions, Your COVID Vaccine May Be Less Effective
Noted: According to a Jan. 6 preprint of a study conducted at the University of Wisconsin-Madison, if you develop a fever while you have COVID, you may be immune to COVID for a longer period of time.
“Such an inflammatory response may be key for developing a strong anti-SARS-CoV-2 antibody response,” according to the study’s authors. And if you want to stay safe, These 3 Things Could Prevent Almost All COVID Cases, Study Finds.
Tracking the effects of glacial melting at the top of the world
Microsoft’s AI for Good Research Lab is working with the International Centre for Integrated Mountain Development (ICIMOD), the University of Wisconsin, and the Quebec AI Institute (Mila). Mila was founded in 1993 by professor Yoshua Bengio, a Canadian computer scientist renowned for his work on artificial intelligence (AI) and neural networks. Professor Bengio was the principal investigator on the project.
Fish reserves work in freshwater too, grassroots movement in Thailand proves
In 2012, Koning, then a doctoral student at the University of Wisconsin, Madison, began investigating the Ngao valley reserves to see how widespread and successful they truly were. Over the next eight years, he spent a total of 18 months living with communities across the region, where he documented around 50 different reserves. He selected 23 to study in depth, interviewing villagers and snorkeling the waters inside and outside the reserves to count and measure fish, along with study co-author Martin Perales.
Externally powered implant designed to treat obesity
That said, scientists at the University of Wisconsin-Madison have developed a battery-free implant that’s powered by stomach movements.
How satellites are stopping deforestation in Africa
This new study, led by Fanny Mofette, a postdoctoral researcher in applied economics at the University of Wisconsin-Madison, looked at the effects of these alert messages on deforestation. Mofette and their team observed an 18% drop over two years in 22 African countries. The carbon emissions avoided with this reduction could be saving anywhere between $149 million and $696 million in economic damages, University of Wisconsin-Madison officials said in a statement.
Extreme weather poses deadly threat to the South’s digital infrastructure
Much of the South’s early communications infrastructure was installed in the 1960s, expanded during the late 1980s and early 1990s, and remains in use today. According to industry experts and data from institutions like the University of Michigan and the University of Wisconsin, Madison, it is nearing the end of its life span. Without serious intervention by federal and state governments, these systems may not hold up to extreme weather events as they grow in intensity and frequency due to climate change.
These African Nations Used Satellite Monitoring to Cut Deforestation by 18 Percent
The research was led by Fanny Moffette, a postdoctoral researcher in applied economics in the Nelson Institute for Environmental Studies and the Department of Agricultural and Applied Economics at the University of Wisconsin–Madison. Moffette collaborated with Jennifer Alix-Garcia at Oregon State University, Katherine Shea at the World Resources Institute, and Amy Pickens at the University of Maryland.
Council Post: How To Incorporate Realistic Optimism Into Your Life
Richard J. Davidson, director of the Center for Healthy Minds at the University of Wisconsin-Madison, has discovered that optimism practitioners are more active on the left side of the prefrontal cortex. This area of the brain, among other circuits, is responsible for our cognitive control and emotional response. Davidson proved that by consciously directing attention, we can influence our emotional reactions.
Deforestation Drops 18% in African Countries Thanks to Satellites
The news should be welcomed by the most hard-nosed of business people and economists as well. According to a recent news article published by the University of Wisconsin-Madison, the savings resulting from the reduction in carbon emissions range anywhere from $149 million to $696 million. These fiscal numbers are “based on the ability of lower emissions to reduce the detrimental economic consequences of climate change.”
It Spied on Soviet Atomic Bombs. Now It’s Solving Ecological Mysteries.
“They counted every rocket in the Soviet Union,” said Volker Radeloff, an ecologist at the University of Wisconsin–Madison whose lab has used the images in its studies. “These images kept the Cold War cold.”
It Spied on Soviet Atomic Bombs. Now It’s Solving Ecological Mysteries.
Over time, Corona cameras and film improved in quality. With an archive of almost one million images, the program detected Soviet missile sites, warships, naval bases and other military targets. “They counted every rocket in the Soviet Union,” said Volker Radeloff, an ecologist at the University of Wisconsin — Madison whose lab has used the images in its studies. “These images kept the Cold War cold.”
Satellite alerts seen helping fight deforestation in Africa
“This is really a small revolution,” said study lead Fanny Moffette, a postdoctoral researcher at the University of Wisconsin-Madison.
Boosting our sense of meaning in life is an often overlooked longevity ingredient
“In the last 10 to 15 years, there has been an explosion of research linking well-being in its many forms to numerous indicators of health. When that work [began], we didn’t know that purpose in life would emerge as such an important predictor of numerous health outcomes,” says Carol Ryff, psychologist at University of Wisconsin-Madison, and director of the MIDUS (Midlife in the United States) national study of Americans. Research has shown that people who have high levels of purpose in life spend fewer nights in hospitals, have lower odds of developing diabetes, and over two times lower risk of dying from heart conditions than do others.
Masks Don’t Mask Others’ Emotions for Kids
Children can still read the emotional expressions of people wearing masks during the COVID-19 pandemic, researchers say.
“We now have this situation where adults and kids have to interact all the time with people whose faces are partly covered, and a lot of adults are wondering if that’s going to be a problem for children’s emotional development,” said study co-author Ashley Ruba, a postdoctoral researcher in the Child Emotion Lab at the University of Wisconsin-Madison.
New research: Kids can identify emotions on masked faces
When masks cover a significant part of the face, how well can people understand the facial expressions of the people wearing them? Children can still understand, to an extent, the expressions on masked faces, according to a new study published in PLOS One.
Despite Challenges, Wisconsin Farmers Projected To End 2020 With Higher Average Income
Quoted: Paul Mitchell, director of the Renk Agribusiness Institute at the University of Wisconsin-Madison, said the forecast is slightly higher than last quarter’s estimate, partly because of a price rally for corn and soybeans seen around harvest time.
“Cash revenues, from soybeans especially, are up compared to where they were in September. It’s rare to have prices go up at harvest when everyone is bringing crops in,” Mitchell said
The 4 Steps That Will Increase Happiness, According To A New Study
Quoted: “It’s a more hopeful view of well-being,” study researcher Cortland Dahl of the University of Wisconsin-Madison’s Center for Healthy Minds, a cross-disciplinary research institute, told HuffPost. “It’s the idea that you can take active steps that improve well-being, very much so in the way that you might take steps to improve physical health.”
Members of Congress send mixed messages on getting vaccinated
Quoted: Alta Charo, a professor of law and bioethics at the University of Wisconsin who consulted on guidelines for prioritizing the COVID-19 vaccine for the National Academies of Science, said showing confidence in the vaccine is good reason for elected officials to be vaccinated early in the process. This may be especially true for Republican leaders. A December poll from ABC News/Ipsos showed Republicans were four times as likely as Democrats to say they would never get the vaccine.
“The amount of vaccine hesitancy that has been created in the last 20 years, 25 years is profoundly disturbing and goes deep into our society. So it takes a long time to build up confidence for people, and people who are unsure,” Charo told ABC News.
Biden and the Underseas Cable: Underworld Massive internet cables may already be below water—but they can still drown.
Quoted: Paul Barford, a University of Wisconsin computer science professor and co-author of a study on the effects of climate change on the internet, sounded less worried about cables sinking anytime soon, because of the financial interests of the telecoms firms involved with cables. But he still says planning now is important. From the get-go, “simply assessing what the current state of this infrastructure is would be something that the government could potentially motivate and potentially help to facilitate,” Barford said. And considering how “unbelievably expensive” these cables are, with costs running into “tens and hundreds of millions of dollars,” it would be a boon if the federal government poured in “funding to help facilitate new deployments or to harden current infrastructure.”
Touchless thermometer tracks COVID-19 symptoms at UW-Madison
A contactless thermometer is helping some UW-Madison students track COVID-19 symptoms, and the thermometer was designed and created on the university’s campus.
Biden Has Vowed To Put Science First To Beat The Pandemic. That Won’t Be Enough.
Quoted: According to Dominique Brossard, a science and risk communication expert at the University of Wisconsin, Madison, that is because, “Humans do not make decisions based on facts. Facts alone do not change our mind.”
Martellus Bennett Writes the Books He Would Have Loved as a Kid
Bennett worries that Black kids aren’t afforded the same opportunities to imagine their way into mischief that white kids are. Surveying the children’s-entertainment landscape, he sees stories in which Black characters either don’t exist or exist merely to satisfy some goal of representation. Black authors are rarer still: According to data collected by the Cooperative Children’s Book Center, at the University of Wisconsin at Madison, less than 5 percent of children’s books published in 2019 were written by Black authors.
Suicides among teen athletes raise mental health concerns
The lead researcher of the study at Wisconsin, Tim McGuine, said in an interview in August that “the greatest risk [to student-athletes] is not covid-19. It’s suicide and drug use.” The study caught the eye of the organization overseeing high school sports, the National Federation of State High School Associations, which was already dealing with an uptick in reports from state athletic directors about mental health concerns for teen athletes whose seasons were in flux.
Revive Therapeutics: The Psychedelics Company Working On A Covid-19 Treatment
Enter Revive Therapeutics, a biotech company with its fingers in several pies: the emerging psychedelics industry, where it has a research partnership with the University of Wisconsin-Madison for formulation development and a clinical trial for substance use using psilocybin; the cannabis industry, where it has patented several unique cannabinoid delivery methods; and more recently, the market for coronavirus treatments, where it is one of fewer than 20 companies undertaking a phase 3 FDA trial—and the one with the lowest market cap.
Madison School District and UW-Madison team up to tackle literacy inequality
The Madison School District and the UW-Madison School of Education announced Monday the formation of a joint early literacy task force to analyze teaching methods for reading and make recommendations to the district to reduce achievement gaps.
A new poll shows the ‘outsized’ financial burdens faced by millennials
Noted: The new Harris Poll was commissioned by DailyPay, the Bipartisan Policy Center Funding Our Future campaign, and The Center for Financial Security at the University of Wisconsin. The survey was conducted online from Nov. 17-19 and surveyed 2,075 U.S. adults ages 18 and older, among whom 593 are millennials between the ages 24-39.
“This data shows the resilience of younger generations in the face of the second major economic shock of their financial lives,” added J. Michael Collins of the Center for Financial Security, referring to this year’s pandemic and the Great Recession of 2007-2009.
Nevermind the political messenger: When it comes to COVID-19 guidance, trust the message, experts say
Quoted: “Research would confirm again and again, when people feel that what’s asked from them is not actually followed by those in power, there’s a sense of betrayal that will occur,” said Dominique Brossard, professor and chair of the Department of Life Sciences Communication at the University of Wisconsin-Madison.
How the leading coronavirus vaccines made it to the finish line
Some scientists believed from the start that it would be possible to repurpose this basic cellular function for medicine. In 1990, a Hungarian-born scientist at the University of Pennsylvania, Katalin Kariko brashly predicted to a surgeon colleague that his work would soon be obsolete, replaced by the power of messenger RNA therapies. That same year, a team at the University of Wisconsin startled the scientific world with a paper that showed it was possible to inject a snippet of messenger RNA into mice and turn their muscle cells into factories, creating proteins on demand.
Scientific journal retracts decades old paper by UW professor due to homophobic content
The Journal of Nervous and Mental Disease flagged the article, “Observations on Homosexuality Among University Students,” which was written by UW professor Benjamin Glover. The study based itself on psychotherapy work and Glover’s belief that he could “cure” homosexual attraction.
Research inspired by COVID-19: ‘COVID toes’ likely a sign of successful viral response
Over a few weeks, there was nearly a 300% increase of patients in Wisconsin exhibiting the condition compared to 2019, said Lisa Arkin, director of pediatric dermatology at the University of Wisconsin-Madison. Trends were similar across the United States. “This was a real pivot because there aren’t so many dermatologists doing COVID-19 research,” Arkin said. “Suddenly, in the spring, there was an avalanche of patients, many of whom had had symptoms for several weeks.”
Bars played crucial role in COVID-19 outbreak at UW-Madison, study says
MIT professor and physician Jeffry Harris utilized public health data with anonymized smartphone tracking data to reach his conclusion. Harris collected the smartphone data from late August through early October and compared it to COVID-19 cases from the 19 census tracts on and around UW-Madison’s campus.
UW-Madison Primate Research Lab’s history of complaints from animal rights groups
A recent complaint against the Wisconsin National Primate Research Center (WNPRC) over mistreatment of animal research subjects at UW-Madison is just one item in a decades-long list of grievances animal rights groups have brought against the laboratory.
Research inspired by COVID-19: UW Hygiene lab uses wastewater samples to detect trends
The Wisconsin State Laboratory of Hygiene and the Department of Health Services are collecting samples from over 100 wastewater treatment facilities, the largest network of its type yet, to trace patterns in the spread of COVID-19.
Research inspired by COVID-19: Dipo Oyeleye examines African music as pandemic response
But while there have been some songs here and there, Dipo Oyeleye, a graduate student at the University of Wisconsin-Madison, said European and American music have largely been devoid of COVID-19 topics.
Research inspired by COVID-19: UW work on genetic sequencing traces community spread
Genetic sequencing of SARS-CoV-2 — the novel coronavirus that causes COVID-19 — reveals that the virus, which was once distinct between Dane and Milwaukee Counties, now reflects patterns of geographic mixing across the state, according to a paper published by University of Wisconsin-Madison researchers this month.
Canadian illustrator Julie Flett’s books reveal the truth about modern Indigenous life
Only 46 out of 4,035 books for children and teens reviewed in 2019 were by Indigenous authors, according to data compiled by the Cooperative Children’s Book Center at the University of Wisconsin-Madison.
Research inspired by COVID-19: Luis Columna brings exercise to children with autism virtually
Fit Families, now based at the University of Wisconsin-Madison, started as an extension of Columna’s work in Guatemala for children with visual impairments, but now offers workshops for children with autism.
New data suggests geographic mixing of COVID-19 strains within Wisconsin
University researchers Thomas Friedrich and David O’Connor, and their labs, analyzed the spread of the coronavirus in a Nov. 3 study published in Nature Journal. The initial data indicated Dane and Milwaukee Counties had limited genetic mixing, with reduced rates of spread after Gov. Tony Evers’ Safer at Home executive order was implemented.
Leaf-cutter ants are coated in rocky crystal armor, never before seen in insects
The discovery is especially surprising because the ants are well known. “There are thousands of papers on leaf-cutter ants,” says study co-author Cameron Currie, an evolutionary biologist at the University of Wisconsin-Madison.
Did Viruses Create the Nucleus? The Answer May Be Near.
Quoted: Just this year, researchers spotted pores in the double-membrane-bound viral factories of coronaviruses, which are eerily reminiscent of the pores found in cell nuclei. “If this result holds up, and assuming that the pore-forming protein was not derived from a eukaryotic genome, then it does blunt one argument against the virus model,” wrote David A. Baum, an evolutionary biologist at the University of Wisconsin, Madison, in an email.
Leaf-cutter ants have rocky crystal armor, never before seen in insects
Quoted: The discovery is especially surprising because the ants are well known. “There are thousands of papers on leaf-cutter ants,” says study co-author Cameron Currie, an evolutionary biologist at the University of Wisconsin-Madison.
“We were really excited to find [this in] one of the most well-studied insects in nature,” he says.
UW Doctor says AstraZeneca vaccine news promising
We now have the first data released from a third covid-19 vaccine, the one in trials here in Madison. The AstraZeneca vaccine seems to be the least effective of the three so far.