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Brilliant Issue: Game Changers

Skin game: First James Thomson created a controversy; then he resolved it. In 1998, Thomson became the first scientist to isolate human stem cells, which can develop into any tissue in the body and thus have tremendous medical potential. Researchers are currently working to figure out how to “instruct” these cells to replace damaged tissues. But the science has been bogged down in controversy, because until recently the cells could be harvested only from embryos.

Last fall, Thomson, 49, announced that he had caused a human skin cell to revert to a stem cell that was virtually identical to those found in embryos. The achievement could open the floodgates of investment. How soon might this bear fruit? “In my lifetime,” Thomson says.