Noted: In 2010 and 2011, the labs of Yoshihiro Kawaoka at the University of Wisconsin–Madison and Ron Fouchier of Erasmus Medical Center in the Netherlands separately announced that they had succeeded in making the deadly H5N1 avian flu virus more transmissible through genetic engineering. Since it first spilled over from poultry to human beings in Hong Kong in 1997, H5N1 has infected and killed hundreds of people in sporadic outbreaks, mostly in Asia. The virus has a roughly 60 percent fatality rate among confirmed cases, but fortunately, H5N1 almost never spreads from person to person. Nearly every infection is due to close contact with infected poultry.