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The mice with human tumours: Growing pains for a popular cancer model

Noted: Abel has performed this procedure hundreds of time since she joined Randall Kimple’s lab at the University of Wisconsin–Madison. Kimple, a radiation oncologist, uses PDX mice to carry out experiments on human tumours that would be impractical in people, such as testing new drugs and identifying factors that predict a good response to treatment. His lab has created more than 50 PDX mice since 2011.