In one year, H7N9 influenza’s highly pathogenic (“high-path”) strains have caused as many human infections as the previous four epidemics put together. As of September 20, there have been 1,589 laboratory-confirmed cases, and 39 percent of those people have died. “It was a matter of time,” says the flu expert Yoshihiro Kawaoka, from the University of Wisconsin-Madison. “It wasn’t surprising to see this change.”