“Small, transient episodes of loneliness really motivate people to then seek out social connection,” said Anna Finley, a postdoctoral research fellow at the Institute on Aging at the University of Wisconsin-Madison. “But in chronic episodes of loneliness, that seems to kind of backfire” because people become especially attuned to social threats or signals of exclusion, which can then make it scary or unpleasant for them to interact with others.