“There is simply too much uncertainty about what happens next,” David O’Connor, a professor of pathology and laboratory medicine at the University of Wisconsin, told The Daily Beast. “Will future variants outrun existing vaccines and therapeutics? What will be the impact of long COVID years, and potentially decades, from now? What other challenges can we not foresee three years into COVID-19 that will challenge us collectively in 2025, 2030, 2040 and beyond?”