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The Peculiar 100-Plus-Year History of Convalescent Plasma

In the 1920s and 30s, cities and towns across the country built “serum depots,” says Susan Lederer, a medical historian at the University of Wisconsin-Madison. These hyperlocal blood banks collected and helped distribute blood from disease survivors. While not much is known about these sites, Lederer posits they may have functioned similar to milk depots, responsible for the safe collection and distribution of milk in municipalities. Convalescent serum therapy was used to treat many feared diseases during this period, including pneumonia, measles, meningitis, plague, and scarlet fever. Serum therapy also formed the basis for state-led pneumonia control programs in the late 1930s, adds Podolsky.