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Category: Research

An Engineered Doomsday

New York Times

Scientists have long worried that an influenza virus that has ravaged poultry and wild birds in Asia might evolve to pose a threat to humans. Now scientists financed by the National Institutes of Health have shown in a laboratory how that could happen. In the process they created a virus that could kill tens or hundreds of millions of people if it escaped confinement or was stolen by terrorists.

Ritalin’s brain target pinpointed by UW researchers

Capital Times

The drug Ritalin has been used for years to help people with attention deficit hyperactivity disorder (ADHD). But it wasn?t until now that researchers at UW-Madison have discovered where in the brain the drug works. Psychology professor Craig Berridge and graduate student Robert Spencer have identified the upper portion of the brain?s prefrontal cortex as the key area where Ritalin works.

Renowned evolutionary biologist and popular professor James Crow dies at 95

Wisconsin State Journal

James F. Crow, one of the world?s most eminent evolutionary biologists and a popular UW-Madison professor for more than 40 years, died Wednesday in Madison. He was 95. The university named its Institute for the Study of Evolution after Crow in 2009.

“Jim was a major figure in the history ? up to the present ? of evolutionary genetics,” said John Hawks, an associate professor of anthropology. In addition to his research on the behavior of genes and the effects of radiation on the human mutation rate, Crow served on a number of groundbreaking national committees. He chaired a national committee that compiled a report on the use of DNA evidence in the courtroom.

Science and Security Clash on Bird-Flu Papers

Chronicle of Higher Education

It was the week before Christmas, and D.A. Henderson was alarmed about germs. He isn?t easily rattled: Dr. Henderson led the successful worldwide effort to eradicate smallpox in the 1970s, and he directed the U.S. Office of Public Health Emergency Preparedness after the deadly anthrax letter attacks and the destruction of the World Trade Center in 2001. But recently not just one but two laboratories had engineered the virus known as bird flu to make it easily transmissible?through the air, among mammals?and that was a scary development. “Compared to plague or to anthrax, this one has a potential for disaster that dwarfs all others,” says Dr. Henderson, now a distinguished scholar at the Center for Biosecurity of the University of Pittsburgh Medical Center. “Given our flu-vaccine capacity, which is limited, this could be a catastrophe if it gets out.” The experiments shouldn?t have been done, in his view, and?partly because they could give terrorists a blueprint for making a more deadly form of H5N1 avian-influenza virus?they certainly shouldn?t be published.

UW-Madison virologist Yoshihiro Kawaoka and Ron Fouchier, a virologist at the Erasmus Medical Center in the Netherlands, are mentioned in this article.

Editorial: On Wisconsin

WISC-TV 3

In a few hours it?ll be all about the football. But it?s been interesting these last several days to hear University of Wisconsin administrators and fans talk about the image boost UW gets from playing in the Rose Bowl. If you haven?t seen the new UW promotional ad, you?ll see it during the game, but it highlights some of the discoveries and research that originated at UW and it?s impressive.

Emmett L. Bennett Jr. Dies at 93, Expert on Ancient Script, Dies at 93 (NYTimes.com)

New York Times

Emmett L. Bennett Jr., a classicist who played a vital role in deciphering Linear B, the Bronze Age Aegean script that defied solution for more than 50 years after it was unearthed on clay tablets in 1900, died on Dec. 15 in Madison, Wis. He was 93. His daughter Cynthia Bennett confirmed the death.

Professor Bennett was considered the father of Mycenaean epigraphy ? that is, the intricate art of reading inscriptions from the Mycenaean period, as the slice of the Greek Bronze Age from about 1600 to 1200 B.C. is known. His work, which entailed analysis so minute that he could eventually distinguish the handwritings of many different Bronze Age scribes, helped open a window onto the Mycenaean world.

Ask the Weather Guys: What were the top Wisconsin weather events for 2011?

Wisconsin State Journal

Each season in 2011 had a memorable weather event, some with negative impacts. There were two good snow storms in February. The Groundhog Day blizzard had wind gusts of up to 60 mph and snowfall depths ranging from 1 to 2 feet. That resulted in snow drifts of 6 to 10 feet. The second storm occurred on February 20-21 with snow accumulations between 8 and 15 inches. Freezing rain and sleet also fell across southern Wisconsin.

….During the year, 10 people were directly killed by weather events: one person from a blizzard, one from lightning, one from a tornado, one from non-tornadic thunderstorm winds, one from flooding and five during the July heat wave.

Anthony S. Fauci, Gary J. Nabel and Francis S. Collins: Dangerous flu virus research a risk worth taking

Capital Times

A deadly influenza virus has circulated widely in birds in recent years, decimating flocks but rarely spreading to humans. Nonetheless, because of its persistence in bird flocks, this highly pathogenic virus has loomed as a major public health threat. Seasonal influenza kills less than 1 percent of the people it infects. In contrast, human infections with the H5N1 virus, though exceedingly rare, are fatal in most cases. Should this virus mutate in a way that allows it to be transmitted as efficiently among people as seasonal influenza viruses are, it could take an unprecedented toll on human life.

A number of important scientific and public health questions regarding this virus remain unanswered, including the likelihood of such mutations arising and the mechanisms by which they may occur. Two recent studies co-funded by the National Institutes of Health (including research conducted by UW-Madison bird flu expert Yoshihiro Kawaoka) have shed light on how this potentially grave human health threat could become a reality.

How to Research Deadly Germs Without Helping Terrorists

Bloomberg News

Bird flu kills more than half the people who catch it. The saving grace of H5N1 is that it?s not easily spread among humans. Almost all of the 600 people who have been infected by the virus in its 14-year history have picked it up from infected poultry.

Patients donate locally to support medical research for personal connections

Wisconsin State Journal

When Greg Szymanski started raising money for eye research, he decided not to give it to a foundation far away. He donated the money to the lab of Dr. David Gamm, a UW-Madison retina specialist using stem cells to better understand and treat vision loss. “I wanted to help right here, where we have specialists who work on these diseases,” said Szymanski, 62, of Madison, who lost most of his sight seven years ago. Unlike government grants that pay for most medical research, Szymanski?s money comes with few restrictions, Gamm said.

Citizen Dave: We might have been a part of it, New York, New York

Isthmus

Imagine if the University of Wisconsin had a campus in New York City dedicated to competing with MIT and Stanford for being the premiere science and high tech research campus in the nation. That possibility was on the table recently when Mayor Michael Bloomberg announced a competition to create a new world-class science campus on underutilized acreage on Roosevelt Island in the East River. The land for the new campus would be given free to the university that competed successfully for it. Bloomberg was offering a $400 million grant in land and infrastructure.

Medtronic paid millions to influential UW chairman

Milwaukee Journal Sentinel

Paul Anderson, an orthopedic surgeon at the University of Wisconsin-Madison, gets so much money from the medical device firm Medtronic that the university put its most stringent oversight on the relationship.

One of the requirements is that Anderson, who has received $225,000 in consulting fees from Medtronic in 2008 through 2010, has to meet annually with his department chairman to review the relationship and its potential influence on his university activities.

But the chairman, Thomas Zdeblick, got more than 25 times that amount from Medtronic himself during the three years. And a new accounting by the Journal Sentinel and MedPage Today shows he received more than $25 million in royalties from the company since 2003.

Science and Censorship: A Duel Lasting Centuries

New York Times

The specter of censorship loomed over science last week with news that a federal advisory panel had asked two leading journals to withhold details of experiments out of fear that terrorists could use the information to make deadly flu viruses ? the first time the government had interceded this way in biomedical research.

Security in H5N1 Bird Flu Study Was Paramount, Scientist Says

New York Times

The National Science Advisory Board for Biosecurity, concerned about bioterrorism and a worldwide pandemic, has for the first time ever urged scientific journals to keep details out of reports that they intend to publish on a highly transmissible form of the bird flu called A(H5N1), which has a high death rate in people.

A Conversation With Jack Williams (The Atlantic)

Atlantic Monthly

In his research, Jack Williams, director of the Nelson Institute Center for Climatic Research, studies the impact climate change had at the end of the last ice age–around 15,000 years ago–when global temperatures rose by 9°F.

By analyzing ancient materials trapped in lake beds, he and his colleagues in the field have come to some startling conclusions. For one, small fluctuations in global temperature can cause large-scale biological changes across the planet, including mass migrations and extinctions.

A Conversation With Jack Williams, Director of the Nelson Institute Center for Climatic Research (The Atlantic)

Atlantic Monthly

As climate change continues to tick the Earths temperature upward, we can learn what to expect of a hotter planet by looking at the past. In his research, Jack Williams, director of the Nelson Institute Center for Climatic Research, studies the impact climate change had at the end of the last ice age–around 15,000 years ago–when global temperatures rose by 9°F. By analyzing ancient materials trapped in lake beds, he and his colleagues in the field have come to some startling conclusions. For one, small fluctuations in global temperature can cause large-scale biological changes across the planet, including mass migrations and extinctions. 

Campus Connection: Feds ask that bird flu study conducted at UW-Madison be censored

Capital Times

A committee that advises the federal government on biosecurity issues is recommending that the details of two experiments on the H5N1 avian influenza virus — including research conducted by UW-Madison bird flu expert Yoshihiro Kawaoka — not be made public due to fears that terrorists could use the information to create a bioweapon.

Feds asked researchers at UW to withhold details about bird flu creation

Wisconsin State Journal

WASHINGTON ? The U.S. government asked scientists at two research centers, including UW-Madison, not to reveal all the details of how to make a version of the deadly bird flu that they created in labs in the U.S. and Europe. Bill Mellon, UW-Madison associate dean for research policy, said virology professor Yoshihiro Kawaoka has gone through several iterations of a manuscript to the journal Nature to comply with the recommendations.

“That is an awkward situation to be in because, obviously, we?re interested in disseminating science,” Mellon said.

Brown Christmas likely for south-central Wisconsin

Wisconsin State Journal

Based on the best and latest weather science, it appears that you will look out your window on Christmas morning and see mostly brown grass. Maybe. Jonathan Martin, professor and chairman of the Department of Atmospheric and Oceanic Sciences at the UW-Madison, said that everything from satellite data to computer models to numerical weather forecasts are telling us that, though snowless Christmases are rarer than skinny mall Santa Clauses, this coming holiday may indeed buck the trend.

UW bird flu research seen as bioterror threat

Milwaukee Journal Sentinel

A University of Wisconsin-Madison scientist who is an expert on the avian flu virus is under scrutiny because of concerns his new research may fall into the wrong hands.

The scientist is Yoshihiro Kawaoka, an eminent professor of virology in the School of Veterinary Medicine who has done research on H5N1, also known as the avian bird flu. His work and similar research independently done by a Dutch scientist have raised concerns in science journals and on an NBC News report that aired Thursday night that touched on such controversial issues as bioterrorism and scientific freedom.

The Bioterrorist Next Door (Foreign Policy)

In September, an amiable Dutchman stepped up to the podium at a scientific meeting convened on the island of Malta and announced that he had created a form of influenza that could well be the deadliest contagious disease humanity has ever faced. The bombshell announcement, by virologist Ron Fouchier of Erasmus Medical Center, sparked weeks of vigorous debate among the world?s experts on bioterrorism, influenza, virology, and national security over whether the research should have been performed or announced and whether it should ever be published.

CDI announces launch of neuron product

Wisconsin State Journal

Cellular Dynamics International is out with a new product: stem cell-derived neurons. The Madison company, founded by UW-Madison stem cell pioneer James Thomson, says it is the first commercial release of human brain cells, created through the company?s stem cell technology, in large enough quantity, quality and purity for use in life science research.

Ann Brenoff: Girls Are Good At Math, New Study Claims

Huffington Post

Back in 2005, then-Harvard president Lawrence Summers proclaimed that boys were simply better at math because, well, because they were boys. It was a statement once-removed from sending the little ladies back into the kitchen with aprons tied around their waists and frankly, the backlash that quickly followed and pulverized Summers was well-deserved.

Skin sample is two million years old? (Pravda)

Many believe that fossils represent organisms that died millions of years ago. Scientific literature, however, contains dozens of well-described original soft tissues in fossils. Since laboratory tests have shown that organic tissues decay in only thousands of years, these fossils have been at the center of much heated controversy.

Ask the Weather Guys: Why does the moon look red during a lunar eclipse?

Wisconsin State Journal

A: A total lunar eclipse could be seen in cloud-free regions across most of the United States and Canada on Saturday morning, Dec. 10. In a total lunar eclipse the sun, Earth and moon line up and the Earth casts its shadow on the moon. The moon is always a full moon and it never goes completely dark during a total lunar eclipse. It appears reddish for the same reason that sunsets and sunrises often have a red tint.