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Category: Research

Severe asthma can be a different form (UPI)

United Press International

MADISON, Wis., Jan. 30 (UPI) — U.S. and British researchers found a physiological difference between severe and non-severe forms of asthma.

The study, published in the Journal of Applied Physiology, compared lung function measurements from 287 people with severe asthma and 382 people with mild and moderate — non-severe — forms of the disease.

Bush speech highlights Wisc. stem-cell research: Dispute in funding of embryonic stem cells still remains

Daily Cardinal

President George W. Bush gave his annual State of the Union address Monday, and his remarks on stem-cell research will likely reverberate in Wisconsin for the last year of his term.

Bush said he was in favor of funding the medical breakthrough by UW-Madison and Japanese researchers that reprogram skin cells to act like embryonic stem cells.

Marquette gets $25 million gift

Milwaukee Journal Sentinel

An anonymous $25 million gift from the family of a Marquette University alumnus takes the school’s vision of a transformed College of Engineering facility beyond the financial halfway mark, university President Father Robert Wild said Tuesday.

Climate is teach-in topic at MATC, UW

Capital Times

Madison Area Technical College and UW-Madison are among about 1,600 institutions nationwide participating in Focus the Nation, a teach-in on global warming solutions. The Thursday event will aim to prepare students to lead responses to the challenges of a changing climate.

Both local programs will feature UW Professor Jon Foley, director of the Nelson Institute’s Center for Sustainability and the Global Environment.

Severe asthma may be different

Scientist Live

A multi-centre research project to investigate severe asthma has found a key physiological difference between severe and non-severe forms of the disease, a finding that could help explain why those with severe asthma do not respond well to treatment.

Ronald Sorkness, a physiologist at the University of Wisconsin in Madison is the lead author of the study.

Study Gives Key Role to Sleep in Helping Brain Learn Anew

New York Times

Researchers who study the brain know that itâ??s far from an immutable object. â??Itâ??s much more plastic than most people think,â? said Giulio Tononi, a psychiatrist at the University of Wisconsin. â??Itâ??s changing all the time.â?

One area of change is the synapses, the connections between neurons, which are altered as the brain receives stimuli. â??What happens when youâ??re awake is you produce an overall strengthening of synapses,â? Dr. Tononi said. â??Thatâ??s good, because thatâ??s how you learn.â?

State of the Union: Bush endorses funding for stem cell research that does not destroy embryos

Wisconsin Technology Network

Washington, D.C. – In his final State of the Union address, President Bush praised a recent discovery that produces cells that act as human embryonic stem cells without destroying human embryos, and indicated his support for expanded federal funding for such research.

While Bush stopped short of making a specific funding proposal, he urged assembled members of Congress to expand funding for stem cell research that does not destroy embryos.

Shelters urged to step up immunization efforts

Wisconsin Radio Network

A UW study reveals low rates of vaccination for the nation’s puppies and kittens. They may be cute and cuddly, but the study by UW’s School of Veterinary Medicine reveals fewer than half of all puppies and kittens are being vaccinated. UW’s Dr. Ron Schultz says the low vaccination rate can be a real problem at animal shelters, and he’d like to see new efforts.

Milfred: Guv pleases left and right

Wisconsin State Journal

Social conservatives used to scowl at the work of UW-Madison stem cell scientist James Thomson, whom Doyle introduced during his speech. But Thomson has quickly become a pro-life hero for reverting human skin cells back to their embryonic state. The technique should eventually allow researchers to develop better drugs and even cures for disease without destroying — or even using — embryos.

UW Vets Perform Surgery On Exotic Tortoise

WISC-TV 3

MADISON, Wis. — Doctors at the University of Wisconsin-Madison School of Veterinary Medicine performed a first-of-its-kind surgery on an exotic yellow-footed tortoise.

The tortoise, named Baskin Robbins, lives at the Milwaukee County Zoo. His caretakers noticed that Baskin Robbins wasn’t walking and appeared to be in pain, so they sent him to Madison for a checkup.

“Baskin Robbins is here because he is lame, meaning he’s not bearing weight on his front left leg, and we think it’s because he had a problem with his humerus, which is the arm bone. Part of it has broken off, and that part needs to be removed so that he’s not lame and in pain,” said Dr. Gretchen Cole, a veterinarian at the UW-Madison School of Veterinary Medicine.

The Scientist’s Eye and the art of technology at the UW

Isthmus

Classes are now in session at UW-Madison, which means that students are once again dozing through lectures, flirting at the library and drinking heavily at their favorite downtown taps. But I issue this plea to Badger undergraduates: Make good use of your time here.

The University of Wisconsin is a world-class institution. You’ll likely never have a better chance to read great books and talk about them with thoughtful people. And you’ll likely never again be amid such a concentration of brilliant lectures, concerts, exhibits, films and other provocative events. As ever, there is a lot going on, all over campus.

Rob Zaleski: Overpopulation issue overlooked by presidential candidates

Capital Times

I kept thinking that at some point during the long, laborious process to elect our next president it was bound to happen. But now, after more than 20 debates and with the election just 10 months away, it has dawned on me that none of the candidates — or any of the media — is going to bring up what the late Gaylord Nelson, the former Wisconsin senator and governor and the father of Earth Day, felt was the most urgent issue that humanity faces: overpopulation.

Quoted: Botany professor Don Waller

Curiosities: Sun could get real hot 5 billion years from now

Wisconsin State Journal

Q. Will the sun ever burn up the Earth and, if so, when?
— Submitted by Noelle Yeazel, Grade 6, Whitehorse Middle School

A. Like all stars, the sun changes over time, and some day — when it has consumed all of its hydrogen fuel and becomes what astronomers call a “red giant star ” — its outer layers could reach as far as the Earth and swallow our planet.

Diseases will flourish without pet vaccinations

Capital Times

Nationwide, fewer than half of all puppies and kittens are vaccinated, according to a study by University of Wisconsin-Madison veterinarians, suggesting that dangerous diseases like distemper and parvovirus will continue to flourish.

“A population must reach a certain threshold of immunity — called ‘herd immunity’ — in order to protect the whole group,” said Ronald Schultz, a vaccinologist who heads a department in the UW-Madison School of Veterinary Medicine. “If not enough individuals in a population are protected, disease can always find a new foothold, or even worse, remain active in the population.”

Whatâ??s the beef?

Daily Cardinal

On Jan. 15, the FDA announced the meat and milk from cloned cows, pigs and goats to be as safe as the food products from their natural counterparts, and would be permitted to enter the U.S. food supply unlabeled.

Algae could be key to faster computer chips

Capital Times

The key to the next big computer chip breakthrough could be tiny algae that encase themselves in intricately patterned, glass-like shells.

The unicellular algae, called diatoms, exist in oceans, lakes and even wet soil and build their hard cell walls by laying down microscopic lines of silica, a compound related to the key material of the semiconductor-industry silicon.

“If we can genetically control that process, we would have a whole new way of performing the nanofabrication used to make computer chips,” Michael Sussman, a UW-Madison biochemistry professor and director of the UW-Madison’s Biotechnology Center, said in a UW press release.

Cormorant reduction planned

Milwaukee Journal Sentinel

Mentions that field studies in 2004, 2005 and 2006 by the University of Wisconsin-Madison concluded that cormorants did not affect yellow perch populations, a key sport fish in Lake Michigan waters.

State of the State: Doyle touts high-tech proposals

Wisconsin Technology Network

In his speech, Doyle also praised University of Wisconsin-Madison stem cell researcher James Thomson, who was in attendance, and UW research teams for embarking on the next frontier of stem cell research – using skin cells to create new stem cells for use in medical research. He also noted the forthcoming groundbreaking on the Wisconsin Institutes for Discovery, a new research center that will foster collaboration between biotechnology, nanotechnology, and information technology.

Outdoors: Large-scale effort needed to save grassland birds

Capital Times

WISCONSIN DELLS — Of all of the birds that spend part of their lives in Wisconsin, the group that needs the most help are grassland birds. Their populations, along with their habitat, are in decline.

That is one of the reasons why the Department of Natural Resources held a statewide Grassland Bird Symposium last week, bringing together state and federal wildlife managers and researchers, and land managers from (non-governmental conservation organizations.

UW-Madison wildlife ecology research associate Kevin Ellison and the UW Arboretum are mentioned.)

Algae may lead to new computer chips

United Press International

MADISON, Wis., Jan. 22 (UPI) — U.S. scientists say the study of diatoms — algae that encase themselves in patterned, glass-like shells — might lead to an advance in computer chips.

University of Wisconsin-Madison researchers said the tiny unicellular phytoplankton build their hard cell walls by depositing submicron-sized lines of silica, a compound related to silicon.

Thomson: Wisconsin needs $50M annually to counter California’s stem cell investment

Wisconsin Technology Network

Madison, Wis. – The University of Wisconsin-Madison professor who first isolated human embryonic stem cells said Tuesday that Wisconsin would have to spend $50 million annually on stem cell research to keep pace with California on a per capita basis.

James Thomson, who spoke on the past and future of stem cell research at the monthly luncheon of the Madison chapter of the Wisconsin Innovation Network, said Stanford and the University of California-San Francisco, alone, receive on the order of $15 million a year a piece.

Thomson says hopes of immediate stem cell therapies unrealistic

www.wisbusiness.com

New stem cell breakthroughs hold great potential for human medicine, UW-Madison researcher Jamie Thomson said today, but any therapies coming from them may be a decade or two off.

â??This will revolutionize human medicine, but mostly it is about the basic science and biology and having access to things we did not have access to before,â? he said, noting that transplantation of stem cells to the central nervous system will be particularly difficult.

UW Prof: Negative ads work (Wispolitics.com)

The public hates negative ads. At least thatâ??s what the media and pundits offer up every election year.

But UW-Madison political science professor Ken Goldstein argues theyâ??re usually more accurate, more likely to focus on substance and policy, and more likely to spark votersâ?? interest and participation. In short, they work.

Goldstein said past claims that negative ads are detrimental to democracy are false and based on faulty assumptions. He builds his case in a new book â??Campaign Advertising and American Democracy.â?

Ebola vaccine possible as researchers defang and isolate strain of virus

Capital Times

A team of University of Wisconsin-Madison researchers has safely isolated a strain from the lethal Ebola virus that may break down some research safety restrictions and foster the development of a vaccine.

The discovery genetically disarms the virus and confines it to a set of specialized cells, making it easier and safer for study.

“We wanted to make biologically contained Ebola virus,” Yoshihiro Kawaoka, the team’s research leader, said in a statement. “This is a great system.”

UW prof: Neagtive ads work (WisPolitics.com)

The public hates negative ads. At least thatâ??s what the media and pundits offer up every election year.

But UW-Madison political science professor Ken Goldstein argues theyâ??re usually more accurate, more likely to focus on substance and policy, and more likely to spark votersâ?? interest and participation. In short, they work.

UW scientist gains a step on Ebola

Wisconsin State Journal

A UW-Madison scientist who had to stop doing some Ebola virus research on campus because of biosafety concerns has plucked a vital gene from the deadly virus to create a version he and others say is safe to use in most labs.

Yoshihiro Kawaoka created the altered live Ebola virus more than a year ago in a high-level biosafety lab in Canada. He has been working with the altered virus at UW-Madison for about a year in a lab with basic biosafety standards, he said.

Disarmed Ebola virus to aid quest for vaccine

The Times, UK

Scientists disarmed the Ebola virus by removing a single gene, providing a new laboratory tool that will help the development of drugs and vaccines against the lethal tropical disease.

Efforts to find ways of treating Ebola, a haemorrhagic fever that kills between 50-90 per cent of the people it infects, have so far been greatly held up by its extreme virulence. The extreme health hazard posed by the virus means that it can be studied only in highly specialised laboratories equipped to biosafety level four (BSL 4), the highest category of containment facility.

‘Safe Ebola’ created for research

BBC News Online

Scientists have made the lethal virus Ebola harmless in the lab, potentially aiding research into a vaccine or cure.

Taking a single gene from the virus stops it replicating, US scientists wrote in the Proceedings of the National Academy of Sciences journal.

Ebola, currently handled in highly secure labs, kills up to 80% of those it infects.

Disarmed Ebola virus to aid research (The Australian)

SCIENTISTS have disarmed the Ebola virus by removing a single gene, providing a new laboratory tool that will help the development of drugs and vaccines against the lethal tropical disease.

Efforts to find ways of treating Ebola, a haemorrhagic fever that kills between 50 and 90 per cent of the people it infects, have so far been greatly held up by its extreme virulence.

Disarmed Ebola raises hope of winning battle (AFP)

Chicago – US researchers have devised a way to genetically disarm the deadly Ebola virus in a development that could speed research into a vaccine against the bug or drugs to treat people who have been infected with it, a study released Monday said.

The investigators discovered removing a single gene from the virus prevents it from replicating or multiplying, effectively neutralizing the bug and making it much safer to study.

Brain activity goes down during sleep

United Press International

MADISON, Wis., Jan. 21 (UPI) — Contrary to the popular belief, the brain is busy consolidating information during sleep, the brain is actually shutting down, a U.S. study found.

Animal studies, published in Nature Neuroscience, found molecular and electro-physiological measures taken on rats showed the neurochemical processes underlying learning — synapses — actually weaken during sleeping hours.

The findings support the synaptic homeostasis hypothesis proposed by the study ‘s lead researchers Chiara Cirelli and Giulio Tononi of the University of Wisconsin, Madison. They said that during sleep the synapses actually “downsize” in preparation for a new round of learning during waking hours.

‘Safe’ form of Ebola created

Nature

A ‘safe’ version of Ebola has been developed by researchers hoping to broaden opportunities to study the deadly virus. If approved by national regulatory authorities, the non-infectious virus could be studied in a broader variety of labs, removing a major roadblock to finding a cure.

Algae could be key to computer chip breakthrough

CBC News

A type of algae found in oceans, lakes and wet soil could be used to create a new, faster generation of computer chips, U.S. researchers suggest in a study released Monday.

Marine diatoms, a unicellular algae, build their hard, patterned cell walls with microscopic lines of silica â?? a compound related to silicon, which is a key material for constructing computer chips and semiconductors.

“If we can genetically control that process, we would have a whole new way of performing the nanofabrication used to make computer chips,” lead researcher Michael Sussman, a University of Wisconsin-Madison biochemistry professor, said in a release.

Scientists modify Ebola virus, hope to speed drug development (Thomson Financial)

Forbes

CHICAGO (Thomson Financial) – US researchers have devised a way to genetically disarm the deadly Ebola virus in a development that could speed research into a vaccine against the bug or drugs to treat people who have been infected with it, a study released Monday said.

The investigators discovered that by removing a single gene from the virus, they can prevent it from replicating or multiplying, effectively neutralizing the virus and making it much safer to study.

Sleep more to learn more

Scientist Live

Most people know it from experience: After so many hours of being awake, your brain feels unable to absorb any moreâ??and several hours of sleep will refresh it.

Now new research from the University of Wisconsin School of Medicine and Public Health clarifies this phenomenon, supporting the idea that sleep plays a critical role in the brainâ??s ability to change in response to its environment. This ability, called plasticity, is at the heart of learning.

Reporting in the Jan. 20, 2008, online version of Nature Neuroscience, the UW-Madison scientists showed by several measures that synapses â?? nerve cell connections central to brain plasticity â?? were very strong when rodents had been awake and weak when they had been asleep.

Scientists render Ebola harmless

Scientist Live

The deadly Ebola virus, an emerging public health concern in Africa and a potential biological weapon, ranks among the most feared of exotic pathogens.

Due to its virulent nature, and because no vaccines or treatments are available, scientists studying the agent have had to work under the most stringent bio-containment protocols, limiting research to a few highly specialized labs and hampering the ability of scientists to develop countermeasures.

New Protein Antifreeze Improves Ice Cream (LiveScience)

A few sharp ice crystals ruin ice cream’s silky texture, as all connoisseurs know. An edible, tasteless antifreeze may soon come to the rescue.

The non-toxic antifreeze, made from a gelatin protein, could be added to any frozen food to prevent unappetizing ice crystals from forming, without otherwise affecting the food itself.

“This has been a major problem in frozen foods,” said food scientist Srinivasan Damodaran of the University of Wisconsin at Madison, who conducted the research. “Ice crystal growth can change properties of frozen food like texture. We live in Wisconsin â?? dairy country. We produce a lot of ice cream.”

Editorial: ‘Brain to Five’ initiative good for public

Appleton Post-Crescent

Area parents eager to understand what’s behind their baby’s coos, their toddler’s meltdowns or their preschooler’s grasp of language are in luck.

The Appleton Education Foundation is hosting four leading “brain investigators” from the University of Wisconsin-Madison’s Waisman Center who will speak about brain development in young children in a series of free lectures beginning next month.

States vie for stem-cell scientists (Stateline.org)

Far from resolving an epic moral quandary, last yearâ??s groundbreaking discovery that ordinary skin cells eventually could replace the use of human embryos in stem-cell research actually stoked the fiery debate over the cutting-edge science.

Religious opponents hailed the skin-cell breakthrough as proof that research involving the destruction of embryos is unnecessary and must end. Scientists countered that studies on stem cells harvested from human embryos must continue for at least several more years while the new technique is perfected. And the battle went on.

Workforce shortage is real, but solutions must be creative

Wisconsin Technology Network

Guri Sohi, chairman of the Computer Science Department at the University of Wisconsin-Madison, has talked candidly about the declining numbers of his department since the height of the dotcom era in 2000. At that point, the UW Computer Science Department granted about 170 bachelor’s degrees annually, and now is down below 80 per year. It also once granted 100 master’s degrees annually, but that has declined to about 50 per year.

Meanwhile, PhDs have remained stable at roughly 20 per year, but there are some ominous national trends. Roughly 75 percent of all doctorate degrees granted nationally in electrical engineering are going to non-U.S. citizens.

UW-Madison’s experience mirrors the national trends, and several efforts are underway to reverse it. One Wisconsin effort is Powered Up, a consortium of businesses and schools in Dane County working to increase awareness in information technology careers. The group was formed in 1999, and is now engaged in talks with the Information Technology Association of Wisconsin to expand statewide.

Editorial: Radical cooperation

Milwaukee Journal Sentinel

Carlos Santiago’s enterprise on Milwaukee’s east side looks a lot like a business start-up: The University of Wisconsin-Milwaukee has a great idea and big ambitions, but it is strapped for cash and hears plenty of people saying, “Show me.”

Edible antifreeze promises perfect ice cream

New Scientist

Edible antifreeze developed by a US researcher could keep ice cream tasty and smooth, and prevent other frozen foods from being ruined. The antifreeze contains proteins similar to those that help “snow flea” insects survive winter without freezing solid.

The taste of good ice cream depends on a blend of flavour, temperature, and texture â?? what food scientists call “mouth feel”.

Food chemist Srinivasan Damodaran at the University of Wisconsin-Madison, US, thinks he has a better solution. He is experimenting with edible antifreeze made from gelatin, which is much more effective at preventing ice crystals from ruining ice cream, he says.

This South Pole base uplifting

Chicago Tribune

Two of the biggest experiments at the South Pole relate to astrophysics and would rank as major projects anywhere in the world. One is a $19.2 million telescope, run by the University of Chicago, that is looking into dark energy by locating the biggest structures in the universe, distant clusters of galaxies formed billions of years ago.

The other, called Ice Cube, involves freezing thousands of delicate sensors into the ancient, crystal-clear ice thousands of feet beneath the pole in a cube configuration 1 kilometer long on each side. The goal of the $280 million project, led by the University of Wisconsin, is to capture one of the smallest and most elusive things in the universe, subatomic neutrino particles.

Provosts Blast Faust’s Words (The Harvard Crimson)

Top administrators from 11 public research universities released a joint statement last week rebuking University President Drew G. Faust for her recent comments in BusinessWeek, where she was quoted as saying that public universities short on federal funds should leave expensive scientific research to their wealthier peers.

â??We emphatically reject that notion,â? wrote the administrators, who are provosts from schools such as the University of Michigan and the University of Wisconsin at Madison. â??Collectively, our institutions educate more than 380,000 students, produce 1 in every 8 American PhDs, and conduct more than $4.5 billion worth of research every year.â?

The Joy of Learning (Elburn Herald)

Fox Valley Career Center game programming technology teacher Anna Schwein had her students focus on â??entertainmentâ? video games at the beginning of the fall semester in order for them to keep an interest in the topic.

However, there is more to the video game market than shoot ’em ups and sports games, and there is more to her class. A growing aspect of the industry falls under the â??edutainmentâ? genre, or games designed to help children learn while entertaining at the same time. Schwein plans to focus about one-third of the semester on this growing aspect of the industry, she said.

David Williamson Shaffer, assistant professor of learning science at the University of Wisconsin Madison, has devoted a significant amount of time to studying it, having written a book called â??How video games help children learn.â?

Mayek, Hamilton and Duesterbeck: UW has lost incredible asset in Dr. Brooks

Capital Times

Dear Editor:

….We’re not privy to the politics that caused him to leave Madison for North Carolina. But we understand his frustration with being denied research dollars to better understand, study and possibly find a cure for this unfortunate disease. The irony is that Wisconsin has the highest rate of ALS in the country.

We hope that the UW Medical School is truly aware of what a loss this is for our community. We know that, like us, there are many other families and friends who thank him for his dedication to helping understand, diagnose and treat those afflicted with ALS, and for his efforts to boost awareness through MDA fundraising, his own physician practice, support groups and teaching.

Nancy Mayek, Beth Hamilton and Ann Duesterbeck, Verona

Embryos survive stem cells’ creation

Milwaukee Journal Sentinel

In the latest feat of stem cell wizardry, researchers have been able to create viable new lines of embryonic stem cells from human embryos that were not destroyed in the process.

The accomplishment is the newest wrinkle in a rapidly evolving effort to find ways to develop prized human embryonic stem cells without the ethical baggage that has plagued the field since its inception nearly a decade ago. Already, the new method is generating controversy.

This new method differs from a breakthrough late last year by University of Wisconsin-Madison and Japanese researchers in that it uses embryos, not genetically engineered skin cells. In the UW work, those skin cells appear to act like embryonic stem cells, but more research is needed before embryonic stem cell work could be abandoned

Positive Psychology: The Science of Happiness

ABCNEWS.com

What exactly is happening inside the brains of people experiencing joy and happiness?

“It’s a very complicated chemical soup,” explained Dr. Richard Davidson, who has made a life’s work out of studying “happy brains.” His lab at the University of Wisconsin is devoted to understanding how much of our joy level is set at birth, and how much we can control.