In Wisconsin, the NSF Materials AI and Transformation through Research Infrastructure for eXtreme environments Materials Innovation Platform (NSF MATRIX-MIP) will be based at the University of Wisconsin–Madison. NSF MATRIX-MIP will investigate how the chemical and structural complexity of materials influences their performance in extreme environments, like those with high heat or strong radiation. MATRIX-MIP will explore how to use complexity to design and create materials with superior properties in such environments. Researchers will design experiments that use AI to rapidly predict the properties of many new materials, fabricate them using high-throughput synthesis methods and then measure their resulting physical properties.