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Category: Research
Still: Stem cell breakthrough by UW shows why federal research should be broadened
MADISON ââ?¬â?? The world now knows about Hwang Woo-suk, the South Korean researcher whose stem cell work may have been falsified. It was a confidence-shaking revelation for some who support human embryonic stem cell research, and a gleeful ââ?¬Å?I-told-you-soââ?¬Â opportunity for those who do not.
If thereââ?¬â?¢s a positive side to the alleged research abuses in South Korea, it is the contrast with how stem cell science is conducted elsewhere. Hwangââ?¬â?¢s transgressions support what bona fide researchers in the United States have been saying all along: ââ?¬Å?We operate under clear, ethical rules that may take longer to produce research results, but you can count on those results once theyââ?¬â?¢re announced.ââ?¬Â
How to Get Smarter, One Breath at a Time (Time Magazine)
Quoted: Richard Davidson, director of the Laboratory for Affective Neuroscience at the University of Wisconsin.
Smith: They’d put WHAT on Leopold land?
“Riley was the first place Leopold was able to test his ideas,” said Janet Silbernagel, a landscape architect at UW- Madison. “It’s far less known than the shack (Leopold’s own place on the Wisconsin River north of Baraboo), but educationally, it’s great, and it’s much closer to Madison.”
The test of terrorism
Toxins and the fear of their misuse – especially since Sept. 11 – has changed life in the laboratory for many scientists.
Passed in 2002, the Public Health Security and Bioterrorism Preparedness and Response Act requires scientists doing research on any of a number of bacteria, viruses and toxins meet a variety of strict security measures, as well as have employees pass a federal background check. While some researchers say that the regulations are appropriate and reasonable, considering the potential for terrorism, others complain that the requirements impede their work on important issues.
“The constraints are reducing research effectiveness,” says Caitilyn Allen, a professor of plant pathology at the University of Wisconsin-Madison.
Do ants hold key to drug resistance?
Some ants, it seems, are packing more than your picnic lunch.
According to researchers at the University of Wisconsin-Madison, a particular tribe of ants, known as attine ants, have pockets throughout their thick, outer armor crammed full of antibiotic-producing bacteria. They use these bacteria to kill off a parasitic fungus that could destroy their way of being.
New ovarian cancer treatment hailed
A cancer specialist at the University of Wisconsin-Madison says that a new way of treating ovarian cancer will save lives.
The National Cancer Institute is recommending that chemotherapy be pumped directly into the abdomen – in combination with traditional IV chemotherapy – to help women with advanced ovarian cancer live longer.
Ellen Hartenbach, director of gynecologic oncology at the UW-Madison, said Thursday that University of Wisconsin Hospital patients participated in clinical trials led by a Johns Hopkins researcher that produced the results leading to the recommendation.
Skin cholesterol content identifies artery risk (Reuters)
Quoted: James H. Stein and colleagues from the University of Wisconsin Medical School.
Editorial: Saying ‘yes’ to research
When Gov. Jim Doyle vetoed a ban on all forms of human cloning in November, he argued that despite what its supporters claimed, the legislation would go against Wisconsin’s history of biomedical innovation, specifically in the controversial field of embryonic stem cell research.
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“Continuing this research,” Doyle correctly observed then, “is a win-win for our state.” And, we would argue, for the world as well, since many scientists believe that the research may one day lead to cures for a variety of illnesses and ailments.
Less than two months later, scientists at the University of Wisconsin-Madison have underscored the importance of this research with a development that moves their work closer to the day when it may one day actually reap therapeutic dividends.
Vet Med Students Get Pet Perspective Of Katrina (WPR)
(MADISON) Most people measure the scope of a disaster in how many human lives are lost or shattered. For students and staff at the University of Wisconsin�s School of Veterinary Medicine, the loss can also be felt in the many animals that are killed, abandoned or injured during a catastrophe. (5th item.)
UW advances stem cell research
Researchers at UW-Madison have developed two new stem cell lines which are the first of their kind to be grown without the use of animal protein.
Pioneer stem cell researcher James Thomson, working with a team from the private WiCell Research Institute, reported online Sunday in the journal Nature Biotechnology that the two stem cell lines, known as WA15 and WA16, were grown without the use of animal proteins or byproducts, meaning they are free of animal contamination, possibly paving the way for stem cell transplants into humans.
Funds for nuclear reprocessing set off debate
The recent signing of a bill by President Bush that provides $50 million for reprocessing spent nuclear fuel has rekindled a highly charged debate on how to deal with nuclear waste.
Reprocessing exacerbates the problem of nuclear proliferation, is not economical and does not solve the problem of waste disposal, said Allison Macfarlane, a research associate in the Program in Science Technology and Society at the Massachusetts Institute of Technology.
In the meantime, new technology for reprocessing spent nuclear fuel is being developed at a research center that is co-directed by a University of Wisconsin-Madison professor.
U.S. scientists grow stem-cell lines in new medium (Reuters)
WASHINGTON, Jan 1 (Reuters) – Scientists at a laboratory affiliated with the University of Wisconsin-Madison have developed a stem-cell culture medium free of animal cells and used it to derive two new human embryonic stem-cell lines.
Tracing Animals’ Family Tree Proves Tricky
UW-Madison scientists analyzing genetic data from many species in an attempt to construct the animal kingdom’s family tree, have hit a snag.
Bugher: Time to Appreciate UW as Economic Engine
MADISON – University Research Park head Mark Bugher, a former Republican cabinet officer, is spreading the message that UW and its research assets are a treasure often unappreciated close to home.
After recent travels to Europe and Florida, Bugher is convinced that Wisconsin has an economic dynamo in the making — a fact sometimes seen clearer from afar than inside the state’s borders.
And he notes some of the hurdles to full exploitation of the economic engine that is UW.
UW scientists reveal stem-cell advance
UW-Madison scientists have created two new embryonic stem-cell lines, the first grown without animal products, officials say, removing a major obstacle to their potential use as cell therapies in people.
All 22 stem-cell lines available for federal funding, including the five created by UW-Madison researcher James Thomson in 1998, have been grown with animal products such as mouse cells and cow blood proteins.
Discovery keeps pressure on Bush
The creation of the first embryonic stem-cell lines without animal products is a research breakthrough that highlights, yet again, UW-Madison’s pre-eminence in the field.
The new lines also show how close stem-cell research is to life-saving cures and how much closer it could be if the federal government would ease its unreasonable funding restrictions.
UW gets nuclear energy study grant (Wisconsin Radio Network)
Recycling spent fuel could be key to nuclear energy’s future.
A problem: all the space at the nation’s yet to open Yucca Mountain nuclear waste repository is already committed for existing radioactive waste, from the nation’s reactors. Todd Allen is a researcher, at UW Madison.
UW nuke projects gain federal funding
Two UW-Madison projects to study advanced materials and fuels for current and future nuclear reactors have received a total of about $1 million in federal funding.
The funding is from the Department of Energy Nuclear Energy Research Initiative, which supports research and development under three initiatives: Generation IV nuclear energy systems, advanced fuel cycles and nuclear hydrogen.
All cloned stem cell lines are fake, investigative panel says
Investigators at South Korea’s leading university announced Thursday that all of the cloned stem cell lines created by its disgraced star scientist are fake. The Seoul National University panel found that Hwang Woo Suk ââ?¬â? who until recently was celebrated as a pioneer in stem cell research ââ?¬â? lied and did not produce stem cells individually tailored to patients as he had claimed.
State tries to stay ahead of potential bird flu threat
2005 saw a host of committees, task forces, hearings and press conferences devoted to improving – or touting – Wisconsin’s response to a possible outbreak of avian influenza. Though no confirmed human or bird cases of the H5N1 influenza virus have occurred in the United States, the disease has spread rapidly among birds and poultry in Asia and Europe.
Gov. Jim Doyle directed three state departments – Health and Family Services, Natural Resources and Agriculture, Trade and Consumer Protection – to form an Avian Influenza Coordination Team to bolster the state’s preparedness efforts.
….University of Wisconsin-Madison scientists, especially Yoshihiro Kawaoka, have been working on several fronts to fight avian influenza.
Metro talker: Smokers wanted
The University of Wisconsin’s Center for Tobacco Research is looking for up to 700 Madison area smokers for a study intended to compare five stop-smoking treatments.
Altered cells deliver Parkinson’s therapy to brain (Reuters)
NEW YORK (Reuters Health) – Genetically modified nerve ‘progenitor’ cells can be used as mini-pumps to deliver nerve growth factor to the brain, a new study in animals shows.
The results suggest such an approach could be used to treat Parkinson’s disease and other brain diseases in humans, Dr. Clive D. Svendsen of the University of Wisconsin-Madison and colleagues report.
Sean Carroll on Endless Forms Most Beautiful (Science & Theology News)
Sean Carroll, professor of genetics at the University of Wisconsin-Madison, is the author of Endless Forms Most Beautiful, an introduction to the new science of evolutionary developmental biology written for the lay reader.
DNA tests to examine ââ?¬Ë?tailored’ stem cells
Officials at a South Korean university said Monday that they expect results next week from DNA tests meant to determine whether disgraced scientist Hwang Woo Suk made tailored stem cells, as he claims.
Stem-cell researcher Hwang to quit over faked study (Bloomberg News)
Disgraced South Korean scientist Hwang Woo Suk was forced to quit his post at Seoul National University after the college said his pioneering stem-cell research was partly faked.
Hwang, who until last month was feted as a national hero, was flanked by weeping researchers as he apologized for the fabrication of a 2005 study that was heralded as a breakthrough in finding cures for diabetes and Alzheimer’s disease. The government said it is considering cutting funding for his work.
Sean Carroll on “Endless Forms Most Beautiful” (Science and Theology News)
Q&A interview with UW-Madison researcher and author of a book on evolutionary developmental biology.
Onset of period delayed in young diabetic women (Reuters)
Young women with type 1 or insulin-dependent diabetes are apt start menstruating later than young women without diabetes, a University of Wisconsin-Madison study suggests.
What are the 25 most important science questions?
CHICAGO – To celebrate the 125th anniversary of its founding by Thomas Edison, the journal Science asked more than 100 of the world’s top scientists what they thought were the 25 most important scientific questions likely to be answered in the next 25 years.
The 25 big questions range from what is consciousness (the mysterious interplay of brain cells and neurotransmitters that conjures up awareness and the ability to ask questions) to what is the universe made of.
Laboratory ethics: What makes some scientists cheat?
Is it a matter of shoddy work in the lab? A problem of excessive deference by junior researchers to senior scientists? Or does the case of the suspect stem-cell experiments in South Korea – an episode that is shaking the biomedical field worldwide – point to a severe lapse of research ethics?
Stem cells could help repair heart
Researchers at the University of Wisconsin-Madison have demonstrated that embryonic stem cells can develop into three different kinds of heart cells to help recover from a heart attack.
The experiments, performed on mice, could be a step in the right direction toward repairing human heart tissue, said Dr. Timothy Kamp, the lead researcher. He is a UW-Madison stem cell and heart specialist.
Tech firms team up with big universities (San Francisco Chronicle)
Some of Silicon Valley’s largest firms, including Intel Corp. and Hewlett-Packard Co., joined forces with big-name universities like UC Berkeley and Stanford on Monday, announcing a new set of guidelines intended to expedite research collaborations on new technology and eliminate legal wranglings over intellectual property rights.
The Reality Behind King Kong?
It seems like we just can’t get enough of the gigantic ape. Three versions of King Kong have been made. Each one more elaborate than the next. But, could this story of the beauty and the beast have its roots in reality?
Yes, according to Dr. Gregg Mitman, who teaches History of Science and Medical History at UW-Madison. “In part based on a 1920 expedition to film and capture the komodo dragon in Indonesia– this search for a prime evil monster in a prime evil time.”
11-year-old Murder Revisited in Assignment
From new evidence that could render a DNA sample, to questions about the victim’s bloodââ?¬â??alcohol level … there are a few new things Benjamin Broeren’s journalism class discovered about an old murder.
“I think there’s some things that can be pursued and there are certain questions that were not answered,” said Broeren.
UW Lectures in Rural India (WPR)
(MADISON) Science educators at the University of Wisconsin-Madison may soon be able to broadcast their lectures and research presentations via satellite to remote villages in India. It�s part of a new collaboration linking 15 U.S. universities with EDUSAT, the Government of India�s first educational satellite. (Third item.)
Study shows huge upside of island development
Developing Clough Island could add millions to the local economy and create hundreds, even thousands, of jobs, according to an economic impact study conducted by graduate students at the University of Wisconsin-Madison.
Fraud Allegations Plague South Korean Team’s Landmark Research on Stem-Cell Cloning
American biomedical researchers were reeling on Thursday after hearing reports from South Korea that members of a top team of scientists there had admitted to fabricating at least part of a landmark study on embryonic stem cells.
The revelations, the Americans said, had the potential to undermine research on cloning human embryos and developing embryonic-stem-cell lines for treating diseases such as Parkinson’s, Alzheimer’s, and diabetes.
State companies help each other deal with electronic world
A UW-Madison program is quietly finding ways to bring the state’s businesses together to help them solve each other’s problems.
The E-Business Consortium, established seven years ago by industrial engineering professor Raj Veeramani, is designed to help state companies learn from one another and compete successfully in the world of electronic business.
Colleague: Stem cell pioneer admits to faking test results
A collaborator of South Korean scientist Hwang Woo Suk, a hero in his country for his stem cell research, says his colleague has admitted fabricating some of his test results. In May, Hwang and his team published a landmark report in the journal Science announcing that they had created 11 lines, or colonies, of cloned human embryonic stem cells. This achievement made South Korea a leader in this field of research. But a co-author of the report, Roh Sung Il, told Korean television and newspapers that Hwang told him Thursday that most of the supposedly cloned lines were fakes and the fate of the others is unclear.
Progress against Parkinson’s
In a study that could lead to a therapy for people with Parkinson’s disease and other neurological disorders, UW- Madison researchers have used stem cells to deliver a disease-fighting protein to the brains of rats.
The protein, called GDNF, has already shown promise in small trials of Parkinson’s patients.
SWIB to add $50 million to state venture funds
The State of Wisconsin Investment Board has given preliminary approval to allocating up to $50 million to two new venture capital funds proposed by state firms Mason Wells and Venture Investors.
The Mason Wells Biomedical Fund II and Venture Investors Early Stage Fund IV are planned to focus on seed and early stage financing of life science opportunities coming out of Wisconsin universities and medical research facilities, said Monica Jaehnig, Wisconsin private equity portfolio manager. But the investments will not be limited to state firms.
UW makes progress on Parkinson’s (AP)
University of Wisconsin-Madison scientists have used stem cells to deliver a protein to the brains of rats in an experiment that could lead to treatment of Parkinson’s disease and other neurological disorders.
Three Technology Companies Join to Finance Research
BERKELEY, Calif., Dec. 12 – With federal funds for basic computer science research at universities in decline, three of the industry’s leading companies are joining to help fill the void.
University of California computer scientists plan to announce on Thursday that the companies – Google, Microsoft and Sun Microsystems – will underwrite a $7.5 million laboratory on the Berkeley campus. The new research center, called the Reliable, Adaptive and Distributed Systems Laboratory, will focus on the design of more dependable computing systems.
Animals receive human cells
Human stem cells genetically engineered to produce a substance that might protect the brains of Parkinson’s patients were successfully transplanted into the brains of monkeys and rats by University of Wisconsin-Madison scientists, a feat that represents a crucial step in developing a promising treatment for the disease.
Physics star says a few numbers run the cosmos
No one was required to be there, yet physicist Brian Greene filled the Union Theater to the top of its balcony for a discussion on general relativity, quantum physics and his own area of expertise, string theory.
String theory, also called superstring theory, attempts to provide an overall theory of the universe by unifying Albert Einstein’s Special Theory of Relativity and quantum mechanics and proposing that all matter can be described in terms of the vibrations of tiny “strings.”
Robert P. Wollersheim
Robert P. Wollersheim, age 66, passed away peacefully on Sunday, Dec. 11, 2005. He was an electrical engineer for the UW Space Science program and helped develop weather radar and space satellites during the ’60s and ’70s. He was also a professor at UW-Madison in electrical engineering and taught mini-courses on wine appreciation for more than 20 years.
Perish The Thought: A Snowless World
If you are among those grumbling about having to shovel your sidewalk yet again, UW-Madison researcher Stephen Vavrus has some news for you. Without that snow, our planet would be in big trouble.
Vavrus is a climate modeling specialist at the Center for Climatic Research. With reports of melting Arctic ice becoming more frequent, Vavrus did what scientists do: He posed a question.
Biotech executives see obstacles
Three top executives of Milwaukee-area start-ups said Monday that southeastern Wisconsin has the potential but nowhere near the critical mass of companies needed for a vibrant biotech effort.
An educated work force, the relatively new master of science in biotechnology program at the University of Wisconsin-Madison geared toward producing managers, and a desire to develop a biotech industry are all helping efforts in the region and the state, said Frank Langley, chief executive officer at PointOne Systems LLC in Wauwatosa.
UW wants you — to test herb
If you’re catching a cold, and need some quick money for holiday shopping, consider enrolling in a research study to test the effectiveness of echinacea, a popular herbal medicine.
Study participants with a scratchy throat and the sniffles can earn up to $120 in the cold study being conducted by researchers in the department of family medicine at the University of Wisconsin-Madison.
Early emotional deprivation might permanently alter children’s brain chemistry (Los Angeles Times)
Children adopted from abroad often have difficulties adjusting to their new families and to life in the United States, exhibiting poor social skills, problems bonding with new family members and reticence in dealing with strangers.
Those difficulties are generally traced back to emotional deprivation in large orphanages, where infants often outnumber staff by 40 to 1, and caregivers do little more than feed and change the infants.
Wisconsin researchers have found that such deprivation can produce relatively permanent changes in a child’s brain chemistry, impairing production of hormones, such as oxytocin, that are crucial to bonding and social interaction.
UW researchers recreate deadly storm 30 years later
Thirty years after the legendary and controversial sinking of the SS Edmund Fitzgerald in Lake Superior, atmospheric scientists at the UW-Madison and the National Weather Service use modern techniques to recreate the harsh storm.
Shedding light on plant behavior
UW-Madison scientists recently obtained the detailed structure of a light-sensing protein, gaining a better understanding of the mechanics of how light governs plant growth and development. This discovery is the end result of almost 30 years of research in mapping phytochromes, plant proteins that can be manipulated to alter plant behavior to better suit agricultural needs.
UW scientist presents climate study
A University of Wisconsin scientist presented his study on climate change and snow coverage at the American Geophysical Union fall conference in San Francisco last week. The study could help scientists learn more about climate change in the Arctic as carbon dioxide pollution continues to grow in the atmosphere.
Wisconsin K-12 ranks third lowest
The University of Wisconsin may be a leader in scientific research and education, but a study conducted recently indicates primary and secondary science education in Wisconsin is among the worst in the country.
Crash kills UW scientist
A senior scientist at the Waisman Center on the UW campus was killed Friday morning when his car skidded out of control on a slippery rural road and was struck by a pickup truck.
Killed was Vladimir Budker, 64, who lived on Sunrise Ridge Trail in the town of Springfield. Along with his work at the Waisman Center, Budker was a co-founder of the Mirus Bio Corp., a gene therapy firm that has been exploring ways to combat such diseases as muscular dystrophy and anemia.
UW-Madison Vet School Helps Katrina’s Lost Pets
A group of students and faculty from the University of Wisconsin-Madison School of Veterinary Medicine are being credited for coming to the rescue during last summer’s devastating hurricane season. Campus officials say that while most people watched in horror as news details of Hurricane Katrina unfolded, a few dedicated souls traveled south to help by bringing back numerous animals that needed foster care or adoptive homes.
Chemical found in fruit may help prevent prostate cancer
A University of Wisconsin School of Medicine and Public Health research team has found a chemical compound common in many fruits, lupeol, which proved promising in preventing prostate cancer, the second-leading cause of cancer death among men.
UW professor studies Newcastle Disease
University of Wisconsin assistant professor Donald Moynihan recently released a report on avian flu entitled ââ?¬Å?Leveraging Collaborative Networks in Infrequent Emergency Situations.ââ?¬Â
Businesses that sell locally less confident
Dane County businesses that depend on local customers to buy their products are not as confident about adding to sales, profits and employees in 2006 as are companies that sell to a broader base, according to a new report.
The Dane County Economic Survey, released Wednesday, shows that 68.5 percent of companies with clients nationwide expect their earnings to rise next year. But among businesses that operate mainly in the Madison area, 51.8 percent are expecting higher profits in 2006.
Study: Mankind’s Earth footprint growing (UPI)
Wisconsin scientists say agriculture dominates more than a third of the Earth’s landscape and is a major source of global environmental change.